Dey S, Nofal W, Brothag C, Kabi M, Khamamkar A, Choudhari N, and Vijayaraghavan S. PP1γ1 is unable to substitute for the mammal-specific PP1γ2 isoform to support male fertility and sperm function. Reproduction. 2024; REP-24-0256. doi: 10.1530/REP-24-0256.
Kumagai H, Kim S, Miller B, Zempo H, Tanisawa K, Natsume T, Lee SH, Wan J, Leelaprachakul N, Kumagai ME, Ramirez II R, Mehta HH, Cao K, Oh TJ, Wohlschlegel JA, Sha J, Nishida Y, Fuku N, Dobashi S, Miyamoto-Mikami E, Takaragawa M, Fuku M, Yoshihara T, Naito H, Kawakami R, Torii S, Midorikawa T, Oka K, Hara M, Iwasaka C, Yamada Y, Higaki Y, Tanaka K, Yen K, Cohen P. MOTS-c modulates skeletal muscle function by directly binding and activating CK2. iScience. 2024; 111212. doi: 10.1016/j.isci.2024.111212.
Voelkel-Meiman K,Liddle JC,Balsbaugh JL, and MacQueen AJ. Proximity labeling reveals new functional relationships between meiotic recombination proteins in S. cerevisiae. PLOS Genetics. 2024; 10.1371/journal.pgen.1011432.
Barrett J, Naduthodi MIS, Mao Y, Dégut C, Musiał S, Salter A, Leake MC, Plevin MJ, McCormick AJ, Blaza JN, and Mackinder LCM. A promiscuous mechanism to phase separate eukaryotic carbon fixation in the green lineage. Nature Plants. 2024; doi: 10.1038/s41477-024-01812-x.
Lam LN, Sedra A, Kajfasz J, Berges A, Saengpet IS, Adams G, Fairman J, and Lemos JA. Trivalent immunization with metal-binding proteins confers protection against enterococci in a mouse infection model. FEMS Microbes. 2024; xtae031. doi: 10.1093/femsmc/xtae031.
Lacin H, Zhu Y, DiPaola JT, Wilson BA, Zhu Y, and Skeath JB. A genetic screen in Drosophila uncovers a role for senseless-2 in surface glia in the peripheral nervous system to regulate CNS morphology. G3. 2024; 14(9): jkae152. doi: 10.1093/g3journal/jkae152.
Adler L, Lau CS, Shaikh KM, van Maldegem KA, Payne-Dwyer AL, Lefoulon C, Girr P, Atkinson N, Barrett J, Emrich-Mills TZ, Dukic E, Blatt MR, Leake MC, Peltier G, Spetea C, Burlacot A, McCormick AJ, Mackinder LCM, and Walker CE. Bestrophin-like protein 4 is involved in photosynthetic acclimation to light fluctuations in Chlamydomonas. Plant Physiology. 2024; kiae450. doi: 10.1093/plphys/kiae450.
Eskesen NO, Kjøbsted R, Birk JB, Henriksen NS, Andersen NR, Ringholm S, Pilegaard H, and Wojtaszewski JFP. The human AMPKγ3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKγ3-associated activity nor glycogen production in human or mouse skeletal muscle. Acta Physiologica. 2024; e14213. doi: 10.1111/apha.14213.
Zhao R, Yan Y, Dong Y, Wang X, Li X, Qiao R, Zhang H, Cui N, Han Y, Wang C, Han J, Ma Q, Liu D, Yang J, Gu G, and Wang C. FGF13 deficiency ameliorates calcium signaling abnormality in heart failure by regulating microtubule stability. Biochemical Pharmacology. 2024; 225: 116329. doi: 10.1016/j.bcp.2024.116329.
Shen L, Ma X, Wang Y, Wang Z, Zhang Y, Pham HQH, Tao X, Cui Y, Wei J, Lin D, Abeywanada T, Hardikar S, Halabelian L, Smith N, Chen T, Barsyte-Lovejoy D, Qiu S, Xing Y, and Yang Y. Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature Communications. 2024; 15, 2809. doi: 10.1038/s41467-024-47107-9.
Vishnu N, Venkatesan M, Madaris TR, Venkateswaran MK, Stanley K, Ramachandran K, Chidambaram A, Madesh AK, Yang W, Nair J, Narkunan M, Muthukumar T, Karanam V, Joseph LC, Le A, Osidele A, Aslam MI, Morrow JP, Malicdan MC, Stathopulos PB, and Madesh M. ERMA (TMEM94) is a P-type ATPase transporter for Mg2+ uptake in the endoplasmic reticulum. Molecular Cell. 2024. doi: 10.1016/j.molcel.2024.02.033.
Tam BM, Taylor JS, and Moritz OL. Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates. Experimental Eye Research. 2024; 239: 109760. doi:10.1016/j.exer.2023.109760.
Papa A, del Rivero Morfin PJ, Chen B, Yang L, Katchman AN, Zakharov SI, Liu G,Bohnen MS, Zheng V, Katz M, Subramaniam S, Hirsch JA, Weiss S,Dascal N, Karlin A, Pitt GS, Colecraft HM, Ben-Johny M, and Marx SO. A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. The Journal of Clinical Investigation. 2024; 134(5):e176943. doi: 10.1172/JCI176943.
Kafri M, Patena W, Martin L, Wang L, Gomer G, Ergun SL, Sirkejyan AK, Goh A, Wilson AT, Gavrilenko SE, Breker M, Roichman A, McWhite CD, Rabinowitz JD, Cross FR, Wühr M, and Jonikas MC. Systematic identification and characterization of genes in the regulation and biogenesis of photosynthetic machinery. Cell Resource. 2023; 186(25): P5638-5655, E25. doi: 10.1016/j.cell.2023.11.007.
Kido K, Eskesen NO, Henriksen NS, Onslev J, Kristensen JM; Larsen MR, Hingst JR, Knudsen JR, Birk JB, Andersen NR, Jensen TE, Pehmøller C, Wojtaszewski JFP, and Kjøbsted R. AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores. Diabetes. 2023; 72(10): 1397-1408. doi: 10.2337/db23-0358.
Wang L, Patena W, Van Baalen KA, Xie Y, Singer ER, Gavrilenko S, Warren-Williams M, Han L, Harrigan HR, Hartz LD, Chen V, Ton VTNP, Kyin S, Shwe HB, Cahn MH, Wilson AT, Onishi M, Hu J, Schnell DJ, McWhite CD, Jonikas MC. A chloroplast protein atlas reveals punctate structures and spatial organization of biosynthetic pathways. Cell. 2023; doi: 10.1016/j.cell.2023.06.008.
Tornini VA, Miao L, Lee H, Gerson T, Dube SE, Schmidt V, Kroll F, Tang Y, Du K, Kuchroo M, Vejnar CE, Bazzini AA, Krishnaswamy S, Rihel J, and Giraldez AJ. linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells. eLife. 2023; doi: 10.7554/eLife.82249.
De Prisco N, Ford C, Elrod ND, Lee W, Tang LC, Huang K, Lin A, Ji P, Jonnakuti VS, Boyle L, Cabaj M, Botta S, Õunap K, Reinson K, Wojcik MH, Rosenfeld JA, Bi W, Tveten K, Prescott T, Gerstner T, Schroeder A, Fong C, George-Abraham JK, Buchanan CA, Hanson-Khan A, Berstein JA, Nella AA, Chung WK, Brandt V, Jovanovic M, Targoff KL, Yalamanchili HK, Wagner EJ, and Gennarino VA. Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites. Science Advances. 2023; 9(7). doi: 10.1126/sciadv.ade4814.
Hartenian E, Mendez AS, Didychuk AL, Khosla S, and Glaunsinger BA. DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production. Nucleic Acid Research. 2022; 51(1): 82-197. doi: 10.1093/nar/gkac1190.
Fu F, Rao L, Li P, Liu X, Wang Q, Son AI, Gennerich A, and Liu JS. Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking. eLife. 2022; doi: 10.7554/eLife.82218.
Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen B, Yang L, Liu G, Jimenez AS, Eisert RJ, Bradshaw GA, Dun W, Ali SH, Rodriques A, Zhou K, Topkara V, Yang M, Morrow JP, Tsai EJ, Karlin A, Wan E, Kalocsay M, Pitt GS, Colecraft HM, Ben-Johny M, and Marx SO. Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response. Nature Cardiovascular Research. 2022; doi: 10.1038/s44161-022-00157-y.
Wang Y, Noyer L, Kahlfuss S, Raphael D, Tao AY, Kaufmann U, Zhu J, Mitchell-Flack M, Sidhu I, Zhou F, Vaeth M, Thomas PG, Saunders SP, Stauderman K, Curotto de Lafaille MA, and Feske S. Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection. Science Advances. 2022; 8, eabn6552. doi: 10.1126/sciadv.abn6552.
Miller B, Kim S, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, and Cohen P. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE. Molecular Psychiatry. 2022; doi: 10.1038/s41380-022-01769-3.
Lopez LS, Völkner C, Day PM, Lewis CM, Lewis CL, Schneider D, Galvis VC, Cruz JA, Armbruster U,Kramer DM, and Kunz H. The Arabidopsis T-DNA mutant SALK_008491 carries a 14-kb deletion on chromosome 3 that provides rare insights into the plant response to dynamic light stress. Plant Direct. 2022; 6(7): e429. doi: 10.1002/pld3.429.
Perl E, Ravisankar P, Beerens ME, Mulahasanovic L, Smallwood K, Bermu´dez Sasso M, Wenzel C, Ryan TD, Koma´r M, Bove KE, MacRae CA, Weaver KN, Prada CE, and Waxman JS. Stx4 is required to regulate cardiomyocyte Ca2+ handling during vertebrate cardiac development. HGG Advances. 2022; 3(3): 100115. doi: 10.1016/j.xhgg.2022.100115.
Domingo-Vidal M, Whitaker-Menezes D, Mollaee M, Lin Z, Tuluc M, Philp N, Johnson JM, Zhan T, Curry J, and Martinez-Outschoorn U. Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers. Frontiers in Oncology. 2022; doi: 10.3389/fonc.2022.906494
Ramirez-Torres A, Reagan AL, Howard LE, Wiggins E, Vidal AC,Wan J,Miller B, Freedland SJ, and Cohen P. Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities. The Prostate.2022; doi: 10.1002/pros.24398.
Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, and Schoonjans K. SLC25A47 is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. Journal of Hepatology. 2022; 10.1016/j.jhep.2022.05.040.
Apfelbaum AA, Wu F, Hawkins AG, Magnuson B, Jiménez JA, Taylor SD, Wrenn ED, Waltner O, Pfaltzgraff ER, Song JY Hall C, Wellik DM, Ljungman M, Furlan SN, Ryan RJH, Sarthy JF, Lawlor ER. EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma. Clinical Cancer Research. 2022; OF1–OF13. doi: 10.1158/1078-0432.CCR-22-0384.
Liu Z, Jiang M, Liakath-Ali K, Sclip A, Ko J, Zhang RS, and Südhof TC. Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. eLife. 2022; doi:10.7554/eLife.70664.
Iyer J, Gentry LK, Bergwell M,Smith A, Guagliardo S, Kropp PA, Sankaralingam P, Liu Y, Spooner E, Bowerman B, and O’Connell KF.The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number. PLOS Genetics. 2022; doi: 10.1371/journal.pgen.1009799.
Marzio A, Kurz E, Sahni JM, Di Feo G, Puccini J, Jiang S, Hirsch CA, Arbini AA, Wu WL, Pass HI, Bar-Sagi D, Papagiannakopoulos T, and Pagano M. EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion. Cell. 2022; 185(1): 169-183. doi: 10.1016/j.cell.2021.12.005.
Miao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, and Giraldez AJ. The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell. 2022; 82(5): 986-1002. doi: 10.1016/j.molcel.2022.01.024.
Kay Y, Tsan L, Davis EA, Tian C, Décarie-Spain L, Sadybekov A, Pushkin AN, Katritch V, Kanoski SE, and Herring BE. Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats. Nature Communications. 2022; 13(798). doi: 10.1038/s41467-022-28430-5.
Concepcion AR, Wagner II LE, Zhu J, Tao AY, Yang J, Khodadadi-Jamayran A, Wang Y, Liu M, Rose RE, Jones DR, Coetzee WA, Yule DI, and Feske S. The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling. Nature Immunology. 2022; 23: 287-302. doi: 10.1038/s41590-021-01105-x.
Chaudhary R, Albrecht S, Datunashvili M, Cerina M, Lüttjohann A, Han Y, Narayanan V, Chetkovich DM, Ruck T, Kuhlmann T, Pape H, Meuth SG, Zobeiri M, and Budde T. Modulation of Pacemaker Channel Function in a Model of Thalamocortical Hyperexcitability by Demyelination and Cytokines. Cerebral Cortex. 2022; doi: 10.1093/cercor/bhab491.
Shah PP, Saurabh K, Kurlawala Z, Vega AA, Siskind LJ, Beverly LJ. Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis. Neoplasia. 2022; 25: 1-8. doi: 10.1016/j.neo.2021.11.010.
Ozment E, Tamvacakis AN, Zhou J, Rosiles-Loeza PY, Escobar-Hernandez EE, Fernandez-Valverde SL, and Nakanishi N. Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity. eLife. 2021; doi: 10.7554/eLife.74336.
Romero AA, Cobb SA, Collins JNR, Kliewer SA, Mangelsdorf DJ, and Collins III JJ. The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3. PLOS Pathogens. 2021; doi: 10.1371/journal.ppat.1010140.
Kumar S, Haile MT, Hoopmann MR, Tran LT, Michaels SA, Morrone SR, Ojo KK, Reynolds LM, Kusebauch U, Vaughan AM, Moritz RL, SHI Kappe, and Swearingen KE. Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector. Genetics and Molecular Biology. 2021; doi: 10.1128/mBio.02575-21.
Fan Y, Wolford BN, Lu H, Liang W, Sun J, Zhou W, Rom O, Mahajan A, Surakka I, Graham SE, Liu Z, Kim H, Ramdas S, Fritsche LG, Nielsen JB, Gabrielsen ME, Hveem K, Yang D, Song J, Garcia-Barrio MT, Zhang J, Liu W, Zhang K, Willer CJ, and Chen E. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience. 2021; 24(11): 103196 . doi: 10.1016/j.isci.2021.103196.
Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim S, and Cohen P. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Scientific Reports. 2021; 11: 16916. doi: 10.1038/s41598-021-96419-z.
Wang HG, Bavley CC, Li A,Jones RM, Hackett J,Bayleyen Y, Lee FS, Rajadhyaksha AM, and Pitt GS. Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors. JCI Insight. 2021; 6(15): e150698. doi: 10.1172/jci.insight.150698.
Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun J, Lv P, Zhang H, and Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Frontiers in Cellular Neuroscience. 2021; doi: 10.3389/fncel.2021.658586.
Li L, Pastor J, Zhang J, Davidson T, Hu M, and Moe OW. In search of alternatively spliced alpha-Klotho Kl1 protein in mouse brain. FASEB. 2021; doi: 10.1096/fba.2020-00066.
Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, and Abdel-Wahab O. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nature Genetics. 2021; doi: 10.1038/s41588-021-00828-9.
Bertho S, Clapp M, Banisch TU, Bandemer J, Raz E, and Marlow FL. Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition. Development. 2021; 187773. doi: 10.1242/dev.187773.
Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL and Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021; 12, 470. doi: 10.1038/s41467-020-20790-0.
Höhner R, Day PM, Zimmermann SE, Lopez LS, Krämer M, Giavalisco P, Galvis VC, Armbruster U, Schöttler MA, Jahns P, Krueger S, and Kunz H. Stromal NADH supplied by PHOSPHOGLYCERATE DEHYDROGENASE3 is crucial for photosynthetic performance. Plant Physiology. 2021; 186(1): 142-167. doi: 10.1093/plphys/kiaa117.
Wanga Q, Yang J, Wang H, ShanB, Yin C, Yu H, Zhang X, Dong Z, Yu Y, Zhao R, Liu B, Zhang H, and Wang C. Fibroblast growth factor 13 stabilizes microtubules to promote Na+ channel function in nociceptive DRG neurons and modulates inflammatory pain. Journal of Advanced Research. 2020; doi: 10.1016/j.jare.2020.12.009.
Carrigee L, Frick JP, Karty JA, Garczarek L, Partensky F, and Schluchter WM. MpeV is a lyase isomerase that ligates a doubly linked phycourobilin on the β-subunit of phycoerythrin I and II in marine Synechococcus. Journal of Biological Chemistry. 2020; doi: 10.1074/jbc.RA120.015289.
Carrigee LA, Frick JP, Karty JA, Garczarek L, Partensky F, and Schluchter WM. MpeV is a lyase isomerase that ligates a doubly-linked phycourobilin on the β-subunit of phycoerythrin I and II in marine Synechococcus. Journal of Biological Chemistry. 2020; doi: 10.1074/jbc.RA120.015289.
Pareek G, and Pallanck LJ. Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression. PLOS Genetics. 2020; doi: 10.1371/journal.pgen.1009118.
Eisa A, Dey S, Ignatious A, Nofal W, Hess RA,Kurokawa M, Kline D, and Vijayaraghavan S. The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for male fertility. Andrology. 2020; doi: 10.1111/andr.12865.
Ray D, Yun Y, Idris M, Cheng S, Boot A, Iain TBH, Rozen SG, Tan P, and Epstein DM. A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. PNAS. 2020; 117 (28) 16391-16400. doi: 10.1073/pnas.2002499117.
Bayraktar EC, La K, Karpman K, Unlu G, Ozerdem C, Ritter DJ, Alwaseem H, Molina H, Hoffmann H, Millner A, Atilla-Gokcumen GE, Gamazon ER, Rushing AR, Knapik EW, Basu S, and Birsoy K. Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism. Nature Matabolism. 2020; 2:487-498. doi: 10.1038/s42255-020-0206-9.
Hertle A, García-Cerdán JG, Armbruster U, Shih R, Lee JJ, Wong W, and Niyogi KK. A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. PNAS. 2020; doi: 10.1073/pnas.1916946117.
Zhang RS, Liakath-Ali K, and Südhof TC. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. eLife. 2020; 9:e54443; doi: 10.7554/eLife.54443.
Holowiecki A, Linstrum K, Ravisankar P, Chetal K, Salomonis N, and Waxman JS. Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation. Development. 2020; 147:dev185652; doi: 10.1242/dev.185652.
D’Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, and Merry TL. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging. 2020; 12(6): 5244-5258. DOI: 10.18632/aging.102944.
Chojnowski A, Ong PF, Foo MXR. Liebl D, Hor L, Stewart CL, and Dreesen O. Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria. Aging Cell. 2020; doi: 10.1111/acel.13108.
Ghoshal A, Uygun DS, Yang L, McNally JM, Lopez-Huerta VG, Arias-Garcia MA, Baez-Nieto D, Allen A, Fitzgerald M, Choi S, Zhang Q, Hope JM, Yan K, Mao X, Nicholson TB, Imaizumi K, Fu Z, Feng G, Brown RE, Strecker RE, Purcell SM, and Pan JQ. Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Translational Psychiatry. 2022; (Suppl) 10, 29; doi: 10.1038/s41398-020-0685-1.
Liu G, Papa A, Katchman AS, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen B, Kushnir A, Dangas K, Gygi SP, Pitt GS, Colecraft HM, Ben-Johny M, Kalocsay M, and Marx SO. Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics. Nature. 2020; 577: 695-700; doi: 10.1038/s41586-020-1947-z.
Schilit SLP, Menon S, Friedrich C, Kammin T, Wilch E, Hanscom C, Jiang S, Kliesch S, Talkowski ME, Tüttelmann F, MacQueen AJ, and Morton CC. SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility. AJHG. 2020; 106(1): 41-57; doi: 10.1016/j.ajhg.2019.11.013.
Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández AF, Zou Z, Yan S, Levine B, Moe OW, and Hu MC. The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance. FASEB. 2020; doi: 10.1096/fj.201902127R.
Hartman JH, Richie C, Gordon KL, Mello DF, Castillo P, Zhu A, Wang Y, Hoffer BJ, Sherwood DR, Meyer JN, and Harvey BK. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. European Journal of Cell Biology. 2019; doi: 10.1016/j.ejcb.2019.05.002.
Loo TH, Ye X, Chai RJ, Ito M, Bonne G, Ferguson-Smith AC, and Stewart CL. The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity. eLIFE. 2019; 8:e49485 doi:10.7554/eLife.49485.
Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray E, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, and Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature Communications. 2019; 4509. doi: 10.1038/s41467-019-12103-x.
Domingo-Vidal M, Whitaker-Menezes D, Martos-Rus C, Tassone P, Snyder CM, Tuluc M, Philp N, Curry J, and Martinez-Outschoorn U. Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma. Molecular Cancer Research. 2019; 17:9. 10.1158/1541-7786.MCR-18-1191.
Collodet C, Foretz M, Deak M, Bultot L, Metairon S, Viollet B, Lefebvre G, Raymond F, Parisi A, Civiletto G, Gut P, Descombes P, and Sakamoto K. AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR. The FASEB Journal. 2019; 33(11); doi: 10.1096/fj.201900841R.
Contreras H, Wussow F, Fernández-Alarcón C, Bierle C, Nguyen J, Diamond DJ, and Schleiss MR. MVA-Vectored Pentameric Complex (PC) and gB Vaccines Improve Pregnancy Outcome after Guinea Pig CMV Challenge, but Only gB Vaccine Reduces Vertical Transmission. Vaccines. 2019; 7(4): 182; doi: 10.3390/vaccines7040182.
Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, and Ramundo S. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. eLIFE. 2019; 8:e49577; doi: 10.7554/eLife.49577.
Cao Z, Hao Y, Fung CW, Lee YY, Wang P, Li X, Xie K, Lam WJ, Qiu Y, Tang BZ, Shui G, Liu P, Qu J, Kang B, and Mak HY. Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain. Nature Communications. 2019; doi: 10.1038/s41467-019-10835-4.
Voelkel-Meiman K, Cheng S, Parziale M, Morehouse SJ, Feil A, Davies OR, de Muyt A, Borde V, and MacQueen AJ. Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein. PLOS Genetics. 2019; doi: 10.1371/journal.pgen.1008201.
Zhang Q, Narayanan V, Mui KL, O’Bryan CS, Anderson RH, Birendra KC, Cabe JI, Denis KB, Antoku S, Roux KJ, Dickinson RB, Angelini TE, Gundersen GG, Conway DE, and Lele TP. Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. Current Biology. 2019; doi: 10.1016/j.cub.2019.07.021.
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, and Elrod JW. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease. Nature Communications. 2019; 3885. doi: 10.1038/s41467-019-11813-6.
Sangaré L, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors. mBio. 2019; 10 (4) e00808-19. doi: 10.1128/mBio.00808-19.
Song YC, Dohn TE, Rydeen AB, Nechiporuk AV, and Waxman JS. HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development. PLOS Genetics. 2019; doi: 10.1371/journal.pgen.1008165.
Zhu XG, Puthenveedu SN, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, and Birsoy K. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Molecular Cell. 2019; doi: 10.1016/j.molcel.2019.01.037.
Bäck S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, and Harvey BK. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019; doi: 10.1016/j.neuron.2019.01.035.
Sun EW, Guillén-Samander A, Bian X, Wu Y, Cai Y, Messa M, and De Camilli P. Lipid transporter TMEM24/C2CD2L is a Ca2+-regulated component of ER–plasma membrane contacts in mammalian neurons. PNAS. 2019; doi: 10.1073/pnas.1820156116.
Yang B, Xu X, Russell L, Sullenberger MT, Yanowitz JL, Maine E. A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line. PLOS Genetics. 2019; doi: 10.1371/journal.pgen.1007992.
Kronfel CM, Hernandez CV, Frick JP, Hernandez LS, Gutu A, Karty JA, Boutaghou MN, Kehoe DM, Cole RB, and Schluchter WM. CpeF is the bilin lyase that ligates the doubly linked phycoerythrobilin on β-phycoerythrin in the cyanobacterium Fremyella diplosiphon. Journal of Biological Chemistry. 2019; doi: 10.1074/jbc.RA118.007221.
Jeong Y, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, and Pagano M. The ULK1-FBXW5-SEC23B nexus controls autophagy. eLIFE. 2018; 7:e42253. DOI: 10.7554/eLife.42253.
Trychta KA, Bäck S, Henderson MJ, and Harvey BK. KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency. Cell. 2018; 25(7): P1829-1840.
Du L, Sohr A, Yan G, and Roy S. Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient. eLife. 2018; doi: 10.7554/eLife.38137.
Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, and McMahon SB. Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. PNAS. 2018; 115(40): E9298-E9307. doi: 10.1073/pnas.1807704115.
Nakanishi N, and Martindale MQ. CRISPR knockouts reveal an endogenous role for ancient neuropeptides in regulating developmental timing in a sea anemone. eLIFE. 2018; 7:e39742 doi: 10.7554/eLife.39742.
Hoyer MJ, Chitwood PJ, Ebmeier CC, Striepen JF, Qi RZ, Old WM, and Gia K. Voeltz. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. Cell. 2018; doi.org/10.1016/j.cell.2018.08.030.
Leikina E, Gamage DG, Prasad V, Goykhberg J, Crowe M, Diao J, Kozlov MM, Chernomordik LV, and Millay DP. Myomaker and Myomerger Work Independently to Control Distinct Steps of Membrane Remodeling during Myoblast Fusion. Cell. 2018; doi.org/10.1016/j.devcel.2018.08.006.
Bisetto S, Whitaker-Menezes D, Wilski NA, Tuluc M, Curry J, Zhan T, Snyder CM, Martinez-Outschoorn UE, and Philp NJ. Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer. Frontiers in Oncology. 2018; doi.org/10.3389/fonc.2018.00324.
Daemen A, Liu B, Song K, Kwong M, Gao M, Hong R, Nannini M, Peterson D, Liederer BM, de la Cruz C, Sangaraju D, Jaochico A, Zhao X, Sandoval W, Hunsaker T, Firestein R, Latham S, Sampath D, Evangelista M, and Hatzivassiliou G. Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State. Cell Metabolism. 2018; doi: 10.1016/j.cmet.2018.06.003.
Zhao Y, Tan CH, Krauchunas A, Scharf A, Dietrich N, Warnhoff K, Yuan Z, Druzhinina M, Gu SG, Miao L, Singson A, Ellis RE, Kornfeld K. The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes. PLOS Biology. 2018; doi: 10.1371/journal.pbio.2005069.
Rhodehouse K, Cascino K, Aseltine L, Padula A, Weinstein R, Spina JS, Olivero CE, and Van Wynsberghe PM. The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans. G3: Genes, Genomes, Genetics.2018; doi.org/10.1534/g3.118.200392.
Wittkopp TM, Saroussi S, Yang W, Johnson X, Kim RG, Heinnickel ML, Russell JJ, Phuthong W, Dent RM, Broeckling CD, Peers G, Lohr M, Wollman F, Niyogi KK, and Grossman AR. GreenCut protein CPLD49 of Chlamydomonas reinhardtii associates with thylakoid membranes and is required for cytochrome b6f complex accumulation. The Plant Journal. 2018; doi.org/10.1111/tpj.13915.
Berns DS, DeNardo LA, Pederick DT, and Luo L. Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature.2018; doi:10.1038/nature25463.
Nandhu MS, Behera P, Bhaskaran V, Longo SL, Barrera-Arenas LM, Sengupta S, Rodriguez-Gil DJ, Chiocca EA, and Viapiano MS. Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma. Clinical Cancer Research.2018; DOI: 10.1158/1078-0432.CCR-17-1628.
Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, Kline D, and Vijayaraghavan S. Isoform-specific requirement for GSK3α in sperm for male fertility. Biology of Reproduction. 2018; doi: 10.1093/biolre/ioy020.
Tassone P, Domingo-Vidal M, Whitaker-Menezes D, Lin Z, Roche M, Tuluc M, Martinez-Outschoorn U, and Curry J. Metformin Effects on Metabolic Coupling and Tumor Growth in Oral Cavity Squamous Cell Carcinoma Coinjection Xenografts. SAGE Journals. 2017; 158(5): 867-877. doi: 10.1177/0194599817746934.
Wang AS, Ong PF, Chojnowski A, Clavel C, and Dreesen O. Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin. Nature. 2017; doi:10.1038/s41598-017-15901-9.
McNulty DE, Bonnette WG, Qi H, Wang L, Ho TF, Waszkiewicz A, Kallal LA, Nagarajan RP, Stern M, Quinn AM, Creasy CL, Su D, Graves AP, Annan RS, Sweitzer SM, and Holbert MA. A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1. SAGE Journals. 2017; 23(1): 34-46. doi: 10.1177/2472555217732014.
Escobar-Aguirre M, Zhang H, Jamieson-Lucy A, and Mullins MC. Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. PLOS Genetics. 2017; doi: 10.1371/journal.pgen.1006983 .
Zhang Y, Ultsch M, Skelton NJ, Burdick DJ, Beresini MH, Li W, Kong-Beltran M, Peterson A, Quinn J, Chiu C, Wu Y, Shia S, Moran P, Di Lello P, Eigenbrot C, and Kirchhofer D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nature Structural and Molecular Biology. 2017; doi:10.1038/nsmb.3453.
Markowitz TE, Suarez D, Blitzblau HG, Patel NJ, Markhard AL, MacQueen AJ, and Hochwagen A. Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae. PLOS Genetics. 2017; doi.org/10.1371/journal.pgen.1006928.
Garza D, Riley SP, Martinez JJ. Expression of Rickettsia Adr2 protein in E. coli is sufficient to promote resistance to complement-mediated killing, but not adherence to mammalian cells. PLOS One. 2017; doi.org/10.1371/journal.pone.0179544.
Curry J Tassone P, Gill K, Tuluc M, BarAd V, Mollaee M, Whitaker-Menezes D, Rodeck U, Luginbuhl A Cognetti D, Keane W, and Martinez-Outschoorn U. Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma. SAGE Journals. 2017; 157(5): 798-807. doi: 10.1177/0194599817709224.
Dogan T, Gnad F, Chan J, Phu L, Young A, Chen MJ, Doll S, Stokes MP, Belvin M, Friedman LS, Kirkpatrick DS, Hoeflich KP, and Hatzivassiliou G. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle. Journal of Biological Chemistry. 2017; doi: 10.1074/jbc.M117.792754.
Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CJ, McEvoy LM, Sato AK, and Hallam TJ. RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates. Scientific Reports. 2017; 3026; doi:10.1038/s41598-017-03192-z.
Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, and Marks AR. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits. Acta Neuropatholigica. 2017; 134: 749-767. doi:10.1007/s00401-017-1733-7.
Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, Martin C, Checler F, Marks AR, and Chami M. Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor. Journal of Biological Chemistry. 2017; doi: 10.1074/jbc.M116.743070.
Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR and Elrod JW. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature. 2017; 545: 93-97. doi:10.1038/nature22082.
Anderson KA, Huynh FK, Kelsey Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, and Hirschey MD. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metabolism. 2017; 25(4): 838-855.e15. doi: 10.1016/j.cmet.2017.03.003.
Wagner GR, Bhatt DP, O’Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, and Hirschey MD. A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. Cell Metabolism. 2017; 25(4): 823-837.e8. doi: 10.1016/j.cmet.2017.03.006.
Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, and Martinez-Outschoorn U. Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma. 2017; 44(3): 204-217. doi.org/10.1053/j.seminoncol.2017.10.002.
Wang Y, Gao H, Shi C, Erhardt PW, Pavlovsky A, Soloviev DA, Bledzka K, Ustinov V, Zhu L, Qin J, Munday AD, Lopez J, Plow E, and Simon DI. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα. Nature Communications. 2017; doi:10.1038/ncomms15559.
Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, and Cantó C. Mfn2 is critical for brown adipose tissue thermogenic function. The Embo Journal. 2017; DOI: 10.15252/embj.201694914.
Noone S, Ratcliff D, Davis R, Subramanian V, Meuser J, Posewitz MC, King PW, and Ghirardi ML. Expression of a clostridial [FeFe]-hydrogenase in Chlamydomonas reinhardtii prolongs photo-production of hydrogen from water splitting. Algal Research. 2017; 22: 116-121. doi.org/10.1016/j.algal.2016.12.014.
Fédry J, Liu Y, Péhau-Arnaudet G, Pei J, Li W, Tortorici MA, Traincard F, Meola A, Bricogne G, Grishin NV, Snell WJ, Rey FA, and Krey T. The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein. Cell. 2017; 168(5): 904-915; doi: 10.1016/j.cell.2017.01.024.
Goh Q and Millay DP. Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy. eLife. 2017; 10.7554/eLife.20007.
Vikram A, Lewarchik CM, Yoon J-Y, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim Y-R, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung S-B, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nature Medicine. 2017; 23: 361-367. doi:10.1038/nm.4284.
Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, and Wehrens XHT. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circulation Research. 2017; 120:110-119. doi: 10.1161/CIRCRESAHA.116.309977.
Medley J, Kabara MM, Stubenvoll MD, DeMeyer LE, Song MH. Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos. Biology Open. 2017; 6: 17-28; doi: 10.1242/bio.022418.
Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, and Cooper EC. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Molecular Psychiatry. 2016; doi:10.1038/mp.2016.233.
Choudhury SR, Singh AK, McLeod T, Blanchette M, Jang B,Badenhorst P, Kanhere A, and Brogna S. Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster. eLIFE. 2016; eLife 2016;5:e19881.
Newton AA, Schnittker RR, Yu Z, Munday SS, Baumann DP, Neaves WB, and Baumann P. Widespread failure to complete meiosis does not impair fecundity in parthenogenetic whiptail lizards. Development. 2016; doi: 10.1242/dev.141283.
Carmell MA, Dokshin GA, Skaletsky H, Hu Y, van Wolfswinkel JC, Igarashi KJ, Bellott DW, Nefedov M, Reddien PW, Enders GC, Uversky VN, Mello CC, and Page DC. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. eLIFE. 2016; 5:e19993. doi: 10.7554/eLife.19993
Ratajczak J, Joffraud M, Trammell SAJ, Ras R, Canela N, Boutant M, Kulkarni SS, Rodrigues M, Redpath P, Migaud ME, Auwerx J, Yanes O, Brenner C, and Carles Canto. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nature Communications. 2016; 7, 13103. doi:10.1038/ncomms13103.
Xie W, Chojnowski A, Boudier T, Lim JSY, Ahmed S, Ser Z, Stewart C, and Burke B. A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations. Current Biology. 2016; doi: 10.1016/j.cub.2016.07.049.
Stubenvoll M, Medley J, Irwin M, and Song MH. ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. PLOS Genetics. 2016; doi: 10.1101/076604.
Adams Jr. G, Zhou J, Wang W, Wu H, Quan J, Liu Y, Xia P, Wang Z, Zhou S, Jiang J, Mo F, Zhuang X, Thomas K, Hill DL, Aikhionbare FO, He P, Liu X, Ding X, and Yao X. The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration. The Journal of Biological Chemistry. 2016; 291: 20692-20706. doi: 10.1074/jbc.M116.732719.
Kulkarni SS, Joffraud M, Boutant M, Ratajczak J, Gao AW, Maclachlan C, Hernandez-Alvarez MI, Raymond F, Metairon S, Descombes P, Houtkooper RH, Zorzano A, and Cantó C. Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin. Diabetes. 2016; db151725. doi: 10.2337/db15-1725.
Bultot L, Jensen TE, Lai Y, Madsen ALB, Collodet C, Kviklyte S, Deak M, Yavari A, Foretz M, Ghaffari S, Bellahcene M, Ashrafian H, Rider MH, Richter EA, and Sakamoto K. A benzimidazole derivative small molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. American Journal of Physiology. 2016; DOI: 10.1152/ajpendo.00237.2016.
Yuen CYL, Shek R, Kang B, Matsumoto K, Cho EJ, and Christopher DA. Arabidopsis protein disulfide isomerase-8 is a type I endoplasmic reticulum transmembrane protein with thiol-disulfide oxidase activity. BMC Plant Biology. 2016; 16:181. DOI: 10.1186/s12870-016-0869-2.
Hunsperger HM, Ford CJ, Miller JS, Cattolico RA. Differential Regulation of Duplicate Light-Dependent Protochlorophyllide Oxidoreductases in the Diatom Phaeodactylum tricornutum. PLOS One. 2016; doi: 10.1371/journal.pone.0158614.
Voelkel-Meiman K, Cheng S, Morehouse SJ, MacQueen AJ. Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutSγ-Mediated Crossover Formation. Genetics. 2016; DOI: 10.1534/genetics.115.182923.
Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Gopfert MC, Jan LY, Jan YN, and Wang Z. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. PNAS. 2016; 113(26): 7243-7248. doi: 10.1073/pnas.1606537113.
Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, and Jan YN. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016; 90(3): 551-563. doi: 10.1016/j.neuron.2016.03.027.
Barmchi MP, Samarasekera G, Gilbert M, Auld VJ, and Zhang B. Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex. PLOS One. 2016; doi: 10.1371/journal.pone.0153259.
Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, and Cohen P. Naturally occurring mitochondrial-derived peptides are age dependent
regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging. 2016; 8(4): 796-809. doi: 10.18632/aging.100943.
Mackinder LCM, Meyer MT, Mettler-Altmann T, Chen VK, Mitchell MC, Caspari O, Rosenzweig ESF, Pallesen L, Reeves G, Itakura A, Roth R, Sommer F, Geimer S, Mühlhaus T, Schroda M, Goodenough U, Stitt M, Griffiths H, and
Jonikas MC. A repeat protein links Rubisco to form the eukaryotic carbon-concentrating organelle. PNAS. 2016; (Suppl) doi: 10.1073/pnas.1522866113.
Hiemstra JA, Lee DI, Chakir K, Gutiérrez‐Aguilar M, Marshall KD, Zgoda PJ, Cruz Rivera N, Dozier DG, Ferguson BS, Heublein DM, Burnett JC, Scherf C, Ivey JR, Minervini G, McDonald KS, Baines CP, Krenz M, Domeier TL, Emter CA. Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine. Journal of the American Heart Association. 2016; doi: 10.1161/JAHA.116.003277.
Ono NN, Qin X, Wilson AE, Li G, and Tian L. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum). PLOS ONE. 2016; doi: 10.1371/journal.pone.0156319.
Bae H, Chen S, Roche JP, Ai M, Wu C, Diantonio A, and Graf ER. Rab3-GEF controls active zone development at the Drosophila neuromuscular junction. eNeuro. 2016; DOI: 10.1523/ENEURO.0031-16.2016.
Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJF, Wilson SW, Rihel J, State MW, and Giraldez AJ. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 2016; 89(4): 725-733. doi: 10.1016/j.neuron.2015.12.039.
Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina YA, Gibson M, Berglund ED, Justice NJ, and Berdeaux R. Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Molecular Metabolism. 2016; 5(1): 34-46. doi: 10.1016/j.molmet.2015.10.004.
Petrova A, Moffett DF. Comprehensive Immunolocalization Studies of a Putative Serotonin Receptor from the Alimentary Canal of Aedes aegypti Larvae Suggest Its Diverse Roles in Digestion and Homeostasis. PLOS One. 2016; DOI: 10.1371/journal.pone.0146587.
Goeres-Miller JD, Liu Y, Williams C, Smith HE, and O'Connell KF. The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in C. elegans. G3. 2016; doi: 10.1534/g3.115.025577.
Yun YS, Kim KH, Tschida B, Sachs Z,Noble-Orcutt KE, Moriarity BS, Ai T, Ding R, Williams J, Chen L, Largaespada D, and Kim D. mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress. Molecular Cell. 2016; 61: 625-639. doi: 10.1016/j.molcel.2016.01.013.
Li X, Zhang R, Patena W, Gang SS, Blum SR, Ivanova N, Yue R, Robertson JM, Lefebvre P, Fitz-Gibbon ST, Grossman AR, and Jonikas MC. An indexed, mapped mutant library enables reverse genetics studies of biological processes in Chlamydomonas reinhardtii. The Plant Cell. 2016; (Suppl) TPC2015-00465-LSB; doi: 10.1105/tpc.15.00465.
Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, and Bolotina VM. Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease. Nature. 2016; doi:10.1038/ncomms10332.
Ling L, Camilleri ET, Helledie T, Samsonraj RM, Titmarsh DM, Chua RJ, Dreesen O, Dombrowski C, Rider DA, Galindo M, Lee I, Hong W, Hui JH, Nurcombe V, van Wijnen AJ, Cool SM. Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Gene. 2016; 576(1): 292-303; doi: 10.1016/j.gene.2015.10.039.
Soupene E, Kao J, Cheng DH, Wang D, Greninger AL, Knudsen GM, DeRisi JL, and Kuypers FA. Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA. Journal of Lipid Research. 2015; doi: 10.1194/jlr.M065003.
Asundi J, Crocker L, Tremayne J, Chang P, Sakanaka C, Tanguay J, Spencer S, Chalasani S, Luis E, Gascoigne K, Desai R, Raja R, Friedman BA, Haverty PM, Polakis P, and Firestein R. An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies. Clinical Cancer Research. 2015; 21(14): 3252-3262; DOI: 10.1158/1078-0432.CCR-15-0156.
Junttila MR, Mao W, Wang X, Wang B, Pham T, Flygare J, Yu S, Yee S, Goldenberg D, Fields C, Eastham-Anderson J, Singh M, Vij R, Hongo J, Firestein R, Schutten M, Flagella K, Polakis P, and Polson AG. Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer. Science Translational Medicine. 2015; 7(314): 314ra186. DOI: 10.1126/scitranslmed.aac7433.
McCleland ML, Soukup TM, Liu SD, Esensten JH, de Sousa e Melo F, Yaylaoglu M, Warming S, Roose-Girma M, and Firestein R. Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesis. The Journal of Pathology. 2015; 237(4): 508-519. DOI: 10.1002/path.4596.
Chojnowski A, Ong PF, Wong ESM, Lim JSY, Mutalif RA, Navasankari R, Dutta B, Yang H, Liow YY, Sze SK, Boudier T, Wright GD, Colman A, Burke B, Stewart CL, Dreesen O. Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. eLife. 2015; 4:e07759; doi: 10.7554/eLife.07759#sthash.m644F8BC.dpuf.
Cheng S, Ramachandran B, Behrmann A, Shao J, Mead M, Smith C, Krchma K, Arredondo YB, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, and Towler DA. Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR-/- Mice by Restraining Noncanonical Wnt Signals. Circulation Research. 2015; doi: 10.1161/CIRCRESAHA.117.306712.
Ito M, Sferruzzi-Perri AN, Edwards CA, Adalsteinsson BT, Allen SE, Loo T, Kitazawa M, Kaneko-Ishino T, Ishino F, Stewart CL and Ferguson-Smith AC. A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development. Development. 2015; (Suppl) doi: 10.1242/dev.121996.
Liu F, Li D, Yeung Y, Yu L, Kang I,Cha M, Kim JY, Park C, Watson DK, Wang T, and Choi K. Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO reports. 2015; DOI: 10.15252/embr.201439939.
Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri Jr. RA, and Druey KM. A fungal protease allergen provokes airway hyper-responsiveness in asthma. Nature Communications. 2015; doi:10.1038/ncomms7763.
Lee C, Zeng J, Drew BC, Sallam T, Martin-Montalvo A, Wan J, Kim S, Mehta H, Hevener AL, de Cabo R, and Cohen P. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism. 2015; 21(3): 443-454. doi: 10.1016/j.cmet.2015.02.009.
Shanmughapriya S, Rajan S, Hoffman NE, Zhang X, Guo S, Kolesar JE, Hines KJ, Ragheb J, Jog NR, Caricchio R,
Baba Y, Zhou Y, Kaufman BA, Cheung JY, Kurosaki T, Gill DL, and Madesh M. Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Science Signaling. 2015; DOI: 10.1126/scisignal.2005673.
Smith SJ, Gu L, Phipps EA, Dobrolecki LE, Mabrey KS, Gulley P, Dillehay KL, Dong Z, Fields GB, Chen Y, Ann D, Hickey RJ, and Malkas LH. A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer. Molecular Pharmacology. 2015; (Suppl)87(2): 263-276. doi: 10.1124/mol.114.093211.
Petersen SC, Luo R, Liebscher I, Giera S, Jeong S, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, and Monk KR. The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211. Neuron. 2015; 85(4) 755-769. doi: 10.1016/j.neuron.2014.12.057.
Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, and Tessier-Lavigne M. Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit. Cell. 2015; 160(1-2): 161-176. doi: 10.1016/j.cell.2014.11.053.
Tsai K, Chan L, Gibeault R, Conn K, Dheekollu J, Domsic J, Marmorstein R, Schang LM, and Lieberman. Viral Reprogramming of the Daxx Histone H3.3 Chaperone during Early Epstein-Barr Virus Infection. Journal of Virology. 2014; doi: 10.1128/JVI.01895-14.
Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo H, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB. Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition. PLoS ONE. 2014; doi: 10.1371/journal.pone.0115144.
Armbruster U, Carrillo LR, Venema K, Pavlovic L, Schmidtmann E, Kornfeld A, Jahns P, Berry JA, Kramer DM, and Jonikas MC. Ion antiport accelerates photosynthetic acclimation in fluctuating light environments. Nature Communications. 2014; doi: 10.1038/ncomms6439.
Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN. Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila. Cell Reports. 2014; (Suppl) doi: 10.1016/j.celrep.2014.10.034.
Sun Y, Daemen A, Hatzivassiliou G, Arnott D, Wilson C, Zhuang G, Gao M, Liu P, Boudreau A, Johnson L, and Settleman J. Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells. Cancer and Metabolism. 2014; 2(20). doi: 10.1186/2049-3002-2-20.
Midorikawa T, Endow JK, Dufour J, Zhu J, and Inoue K. Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase. The Plant Journal. 2014; doi: 10.1111/tpj.12655.
Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, and King RW. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014; doi: 10.1038/nature13660.
Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY and Jan YN. Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes and Development. 2014; 28:1940-1956.
Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, and Yu H. Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nature Structural & Molecular Biology. 2014; 21: 864–870.
Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, and Sun Y. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLIFE. 2014; doi: 10.7554/eLife.02236.
Clay MR, and Halloran MC. Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition. Development. 2014; 141: 2506-2515.
Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation. PLoS ONE. 2014; doi: 10.1371/journal.pone.0100043.
Qian W, Miki D, Lei M, Zhu X, Zhang H, Liu Y, Li Y, Lang Z, Wang J, Tang K, Liu R, and Zhu J. Regulation of Active DNA Demethylation by an a-Crystallin Domain Protein in Arabidopsis. Molecular Cell. 2014; doi: 10.1016/j.molcel.2014.06.008.
Hiemstra JA, Gutiérrez-Aguilar M, Marshall KD, McCommis KS, Zgoda PJ, Cruz-Rivera N, Jenkins NT, Krenz M, Domeier TL, Baines CP, and Emter CA. A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini‐swine with compensated heart failure. Physiological Reports. 2014; doi: 10.14814/phy2.12050.
Hiemstra JA, Gutiérrez-Aguilar M, Marshall KD, McCommis KS, Zgoda PJ, Cruz-Rivera N, Jenkins NT, Krenz M, Domeier TL, Baines CP, and Emter CA. A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini-swine with compensated heart failure. Physiological Reports. 2014; 2(6): e12050; doi: 10.14814/phy2.12050.
Gutiérrez-Aguilar M, Douglas DL, Gibson AK, Domeier TL, Molkentin JD, and Baines CP. Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. Journal of Molecular and Cellular Cardiology. 2014; 72: 316-325.
Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival. PLoS ONE. 2014; doi: 10.1371/journal.pone.0096866.
Heim AE, Hartung O, Rothhämel S, Ferreira E, Jenny A, and Marlow FL.Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Development. 2014; doi: 10.1242/dev.090449.
Shah P, Lockwood W, Saurabh K, Kurlawala Z, Shannon SP, Waigel S, Zacharias W, and Beverly LJ. Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells. Nature. 2014; doi: 10.1038/onc.2014.97.
Arur S, and Schedl T. Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo. Nature Protocols. 2014; 9, 375–395.
Vanlandingham PA, Barmchi MP, Royer S, Green R, Bao H, Reist N, Zhang B. AP180 Couples Protein Retrieval to Clathrin-Mediated Endocytosis of Synaptic Vesicles. Traffic. 2014; doi: 10.1111/tra.12153.
Coleman JA, Zhu X, Djajadi HR, Molday LL, Smith RS, Libby RT, John SWM, and Molday RS. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. Journal of Cell Science. 2014; doi: 10.1242/jcs.145052.
Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, and Tessier-Lavigne M. Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin. Neuron. 2014; doi: 10.1016/j.neuron.2013.08.034.
Riley SP, Patterson JL, Nava S, and Martinez JJ. Pathogenic Rickettsia species acquire vitronectin from human serum to promote resistance to complement-mediated killing. Cellular Microbiology. 2013; 16(6): 849-861.
Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé M, Ajzenberg D, Fitzgerald K, Young LH, Saeij JPJ. Transcriptional Analysis of Murine Macrophages Infected with Different Toxoplasma Strains Identifies Novel Regulation of Host Signaling Pathways. PLOS Pathogens. 2013; doi: 10.1371/journal.ppat.1003779.
Voelkel-Meiman K, Taylor LF, Mukherjee P, Humphryes N, Tsubouchi H, MacQueen AJ. SUMO Localizes to the Central Element of Synaptonemal Complex and Is Required for the Full Synapsis of Meiotic Chromosomes in Budding Yeast. PLOS Genetics. 2013; 9(10): e1003837. doi: 10.1371/journal.pgen.1003837.
Lee EK, Lian Z, D’Andrea K, Letrero R, Sheng WQ, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L, Amaravaradi R, Xu X, Herlyn M, Nathanson KL, and Diehl JA. The FBXO4 tumor suppressor functions as a barrier to BrafV600E3
dependent metastatic melanoma. Molecular and Cellular Biology. 2013; 33(22): 4422-4433.
Tubon Jr TC, Zhang J, Friedman EL, Jin H, Gonzales ED, Zhou H, Drier D, Gerstner JR, Paulson EA, Fropf R, and Yin JCP. dCREB2-Mediated Enhancement of Memory Formation. The Journal of Neuroscience. 2013; 33(17): 7475-7487.
Ligon LS, Rigel NW, Romanchuk A, Jones CD, and Braunstein M. Suppressor Analysis Reveals a Role for SecY in the SecA2-Dependent Protein Export Pathway of Mycobacteria. Journal of Bacteriology. 2013: doi: 10.1128/JB.00630-13.
Auerbach M, Yan D, Fouts A, Xu M, Estevez A, Austin CD, Bazan F, Feierbach B. Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread. Virology. 2013; 441(1): 75-84.
Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size. Cell Reports. 2013; 3(5): 1465-1475.
Dreesen O, Chojnowski A, Ong PF, Zhao TY, Common JE, Lunny D, Lane EB, Lee SJ, Vardy LA, Stewart CL, and Colman A. Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. The Journal of Cell Biology. 2013; 200(5): 605-617.
Ichinose K, Zhang Z, Koga T, Juang Y, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, and Tsokos GC. Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013; 65(3): 764–769.
Kuchay S, Duan S, Schenkein E, A Peschiaroli, Saraf A, Florens L, Washburn MP, and Pagano M. FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nature Cell Biology. 2013; 15: 472-480.
Tran H, Bustos D, Yeh R,Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS,and Polakis P. HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction. The Journal of Biological Chemistry. 2013; 288(6): 3753–3767.
Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, and Jackson PK. The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling. Cell. 2013; 152(1): 210-223.
Liew CW, Boucher J, Cheong JK, Vernochet C, Koh H, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng Y, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Bluher M, Hsu SI, and Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nature Medicine. 2013; 19:217–226.
Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung P, Schildkraut CL, and Pagano M. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. The Journal of Cell Biology. 2013; 200(2): 141-149.
Eckert C, Boehm M, Carrieri D, Yu J, Dubini A, Nixon PJ, and Maness P. Genetic Analysis of the Hox Hydrogenase in the Cyanobacterium Synechocystis sp. PCC 6803 Reveals Subunit Roles in Association, Assembly, Maturation, and Function. The Journal of Biological Chemistry. 2012; 287:43502-43515.
Rivera-Cancel G, Motta-Mena LB, and Gardner KH. Identification of Natural and Artificial DNA Substrates for Light-Activated LOV–HTH Transcription Factor EL222. Biochemistry. 2012; 51(50): 10024–10034.
Vonderfecht T, Cookson MW, Giddings Jr. TH, Clarissa C, and Winey M. The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies. Molecular Biology of the Cell. 2012; 23(24):4766-4777.
Insinna C, Daniele LL, Davis JA, Larsen DD,Kuemmel C, Wang J, Nikonov SS, Knox BE, and Pugh Jr. EN. An S-opsin knockin mouse (F81Y) reveals a role for the native ligand 11-cis retinal in cone opsin biosynthesis. The Journal of Neuroscience. 2012; 32(23):8094-8104.
Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese Jr. RV, and Mak HY. The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface. The Jounal of Cell Biology. 2012: 198(5):895-911.
Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H, Li X, Li S, Zhu X, Shi X, Zhang K, Pontes O, Chen X, Liu R, Gong Z, and Zhu J. A Histone Acetyltransferase Regulates Active
DNA Demethylation in Arabidopsis. Science. 2012; 336(6087): 1445-1448.
Peel N, Dougherty M, Goeres M, Liu Y, and O'Connel KF. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. Journal of Cell Science. 2012; 125: 3535-3544.
Zhang J, Yu Y, Nakamura K, Koike T, Waqar AB, Zhang X, Liu E, Nishijima K, Kitajima S, Shiomi M, Qi Z, Yu J, Graham MJ, Crooke RM, Ishida T, Hirata K, Hurt-Camejo E, Chen YE, and Fan J. Endothelial Lipase Mediates HDL Levels in Normal and Hyperlipidemic Rabbits. Journal of Atherosclerosis and Thrombosis. 2012;19(3):213-26.
Carrieri D, Paddock T, Maness P, Seiberta M, and Yu J. Photo-catalytic conversion of carbon dioxide to organic acids by a recombinant cyanobacterium incapable of glycogen storage. Energy & Environmental Science. 2012; 5:9457-9461.
Beverly LJ, Lockwood WW, Shah PP, Erdjument-Bromage H, Varmus H. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1
. PNAS. 2012; doi: 10.1073/pnas.1119167109.
Driscoll MK, Albanese JL, Xiong Z, Mailman M, Losert W, and Cao K. Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell? Impact Journal on Aging. 2012; 4(2): 119-132.
Longworth MS, Walker JA, Anderssen E, Moon NS, Gladden A, Heck MMS, Ramaswamy S, and Dyson NJ. A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity. PLOS Genetics. 2012; doi: 10.1371/journal.pgen.1002618.
Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY. Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons. Neuron. 2012; 74(1): 179-192.
Ultanir SK, Hertz NT, Li G, Ge W, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron. 2012; 73(6): 1127-1142.
Song X, Bowen J, Miao W, Liu Y, and Gorovsky MA. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012; 26: 615-629.
Yang H, Zheng Z, Zhao L, Li Q, and Liao D. Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection. Cell Cycle. 2012; 11(3): 582-593.
Mortensen BL, Fuller JR, Taft-Benz S, Collins EJ, and Kawula TH. Francisella tularensis RipA Protein Topology and Identification of Functional Domains. Journal of Bacteriology. 2012; 194(6): 1474-1484.
Kulis M, Chen X, Lew J, Wang Q, Patel OP, Zhuang Y, Murray KS, Duncan MW, Porterfield HS,
Burks AW, Dreskin SC. The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice. Clinical and Experimental Allergy. 2012; 42(2): 326-336.
McCommis KS, McGee AM, Laughlin MH, Bowles DK, Baines CP. Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise.American Journal of Physiology. 2011; 301(5): R1250-R1258.
Du YN, Chou C, Klimstra D, and Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. PNAS. 2011; 108(40): 16753-16758.
Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, and Peterson AS. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nature Cell Biology. 2011; doi:10.1038/ncb2410.
Kant S, Swat W, Zhang S, Zhang Z, Neel BG, Flavell RA,Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes and Development. 2011; 25(19): 2069–2078.
Hsu S, Nafati M, and Inoue K. OEP80, an essential protein paralogous to the chloroplast protein translocation channel Toc75, exists as a 70-kD protein in the Arabidopsis thaliana chloroplast outer envelope. Plant Molecular Biology . 2011; doi: 10.1007/s11103-011-9853-2.
Zhou M, Hu Q, Li Z, Li D, Chen C, and Luo H. Expression of a Novel Antimicrobial Peptide Penaeidin4-1 in Creeping Bentgrass (Agrostis stolonifera L.) Enhances Plant Fungal Disease Resistance. PLoS ONE. 2011; 6(9): e24677.
Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang J, Daigle KR, Fenn JD, Adelman K, and Dudek SM. Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nature Neuroscience. 2011; 14: 848–856.
Biswas A, Boutaghou MN, Alvey RM, Kronfel CM, Cole RB, Bryant DA, and Schluchter WM. Characterization of the Activities of the CpeY, CpeZ, and CpeS Bilin Lyases in Phycoerythrin Biosynthesis in Fremyella Diplosiphon Strain UTEX 481. The Journal of Biological Chemistry. 2011; doi: 10.1074/jbc.M111.284281.
Castorino JJ, Gallagher-Colombo SM, Levin AV, FitzGerald PG, Polishook J, Kloeckener-Gruissem B, Ostertag E, and Philp NJ. Juvenile Cataract-associated Mutation of Solute Carrier SLC16A12 Impairs Trafficking of the Protein to the Plasma Membrane. Investigative Ophthalmology & Visual Science. 2011; 10-6579.
Wang C, Hennessey JA, Kirkton RD, Wang C, Graham V, Puranam RS, Rosenberg PB, Bursac N, Pitt GS. Fibroblast Growth Factor Homologous Factor 13 Regulates Na+ Channels and Conduction Velocity in Murine Hearts. Circulation Research. 2011; doi: 10.1161/CIRCRESAHA.111.247957.
Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, and Yu H. PICH and BLM Limit Histone Association with Anaphase Centromeric DNA Threads and Promote Their Resolution. The EMBO Journal. 2011; 30, 3309-3321.
Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, and Brenner MB. Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b. Journal of Immunity. 2011; doi: 10.1016/j.immuni.2011.06.009.
Huang X, Summers MD, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM. Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry. Molecular Cell. 2011; 42(4):511-523.
Davis EE, Zhang Q, Liu Q, Diplas BH, Davey LM, Hartley J, Stoetzel C, Szymanska K, Ramaswami G, Logan CV, Muzny DM, Young AC, Wheeler DA, Cruz P, Morgan M, Lewis LR, Cherukuri P, Maskeri B, Hansen NF, Mullikin JC, Blakesley RW, Bouffard GG, Gyapay G, RiegerS, Tönshoff B, Kern I, Soliman NA, Neuhaus TJ, Swoboda KJ, Kayserili H, Gallagher TE, Lewis RA, Bergmann C, Otto EA, Saunier S, Scambler PJ, Beales PL, Gleeson JG, ER Maher, Attié-Bitach T, Dollfus H, Johnson CA, Green ED, Gibbs RA, Hildebrandt F, Pierce EA and Katsanis N. TTC21B Contributes Both Causal and Modifying Alleles Across the Ciliopathy Spectrum. Nature Genetics. 2011; doi: 10.1038/ng.756.
Kehat I, Accornero F, Aronow BJ, and Molkentin JD. Modulation of Chromatin Position and Gene Expression by HDAC4 Interaction with Nucleoporins. The Journal of Cell Biology 2011; 193(1): 21-29.
Song MH, Liu Y, Anderson DE, Jahng WJ, and O'Connell KF. Protein Phosphatase 2A-SUR-6/B55 Regulates Centriole Duplication in C. elegans by Controlling the Levels of Centriole Assembly Factors. Developmental Cell 2011: 20(4): 563-571.
Yang Y, Cochran DA, Gargano MD, King I, Samhat NK, Burger BP, Sabourin KR, Hou Y, Awata J, Parry DAD, Marshall WF, Witman GB, and Lu X. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50, Molecular Biology of the Cell. 2011; 22(7): 976-987.
Szuperák M, Salah S, Meyer EJ, Nagarajan U, Ikmi A and Gibson MC. Feedback Regulation of Drosophila BMP Signaling by the Novel Extracellular Protein Larval Translucida. Development. 2011; 138: 715-724.
Hurov KE, Cotta-Ramusino C, and Elledge SJ. A Genetic Screen Identifies the Triple T Complex Required for DNA Damage Signaling and ATM and ATR Stability. Genes and Development. 2010; 24: 1939-1950
Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, and Vucic D. c-IAP1 and UbcH5 Promote K11-linked Polyubiquitination of RIP1 in TNF Signalling
The EMBO Journal. 2010; doi: 10.1038/emboj.2010.300.
Ai M, Min S, Grosjean Y, Leblanc C, Bell R, Benton R, and Suh1 GSB. Acid Sensing by the Drosophila Olfactory System. Nature. 2010; doi: 10.1038/nature09537.
Daniele LL, Insinna C, Chance R, Wang J, Nikonov SS and Pugh Jr. EN. A Mouse M-opsin Monochromat: Retinal Cone Photoreceptors Have Increased M-opsin Expression When S-opsin is Knocked Out. Vision Research.
2010; doi: 10.1016/j.visres.2010.12.017.
McGee AM and Baines CP. Complement 1q binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death. Biochemical Journal. 2010; doi: 10.1042/BJ20101431.
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, and Elledge SJ. A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair. Molecular Cell. 2010; 39(1): 36-47.
Al-Anzi B, Armand E, Nagamei P, Olszewski M, Sapin V, Waters C, Zinn K, Wyman RJ, and Benzer S. The Leucokinin Pathway and Its Neurons Regulate Meal Size in Drosophila. Current Biology. 2010; 20(11): 969-978.
Singh SK, Tan QW, Brito C, De León M and De León D. Insulin-like Growth Factors I and II Receptors in the Breast Cancer Survival Disparity Among African–American Women. Growth Hormone & IGF Research. 2010; 20(3) 245-254.
Gao Z, Liu H, Daxinger L, Pontes O, He X, Qian W, Lin H, Xie M, Lorkovic ZJ, Zhang S, Miki1 D, Zhan X, Pontier D, Lagrange T, Jin H, Matzke AJM, Matzke M, Pikaard CS, and Zhu J. An RNA polymerase II- and AGO4-associated Protein Acts in RNA-directed DNA Methylation. Nature. 2010; doi: 10.1038/nature09025.
Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, and Turner JR. Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions. Molecular Biology of the Cell. 2010; 21(7): 1200-1213.
Gundersen CB, Kohan SA, Souda P, Whitelegge JP, and Umbach JA. Cysteine String Protein β is Prominently Associated with Nerve Terminals and Secretory Organelles in Mouse Brain. Brain Research. 2010: doi: 10.1016/j.brainres.2010.03.044.
Valdivia CR, Medeiros-Domingo A, Ye B, Shen W, Algiers TJ, Ackerman MJ, and Makielski JC. Loss-of-function Mutation of the SCN3B-encoded Sodium Channel β3 Subunit Associated with a Case of Idiopathic Ventricular Fibrillation. Cardiovascular Research. 2010; 0: cvp417v2-cvp417.
Camahort R, Shivaraju M, Mattingly M, Li B, Nakanishi S, Zhu D, Shilatifard A, Workman JL, and Gerton JL. Cse4 is Part of an Octameric Nucleosome in Budding Yeast. Molecular Cell. 2010; 35:6 794-805.
Singh SK, Tan QW, Brito C, De León, M, Garberoglio C, and De León D. Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity. Growth Hormone & IGF Research. 2009; 20(2): 162-170.
Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A, and Molkentin JD. α1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. Journal of Clinical Investigation. 2009; 119(2): 3787-3796.
He XJ, Hsu YF, Zhu S, Liu HL, Pontes O, Zhu J, Cui X, Wang CS, and Zhu JK. A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development. Genes and Development. 2009; 23:2717-2722.
Parry JM, Velarde NV, Lefkovith AJ, Zegarek MH, Hang JS, Ohm J, Klancer R, Maruyama R, Druzhinina MK, Grant BD, Piano F, and Singson A. EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans. Cell Current Biology. 2009; 19(20): 1752-1757; doi: 10.1016/j.cub.2009.09.015.
Isaac J, Hartney SL, Druffel K, and Hadwiger LA. The non-host disease resistance response in peas; alterations in phosphorylation and ubiquitination of HMG A and histones H2A/H2B. Plant Science. 2009; 177:5 439-449.
Nagano T, Kakegawa A, Yamakoshi Y, Tsuchiya S, Hu JCC, Gomi K, Arai T, Bartlett JD and Simmer JP. Mmp-20 and Klk4 Cleavage Site Preferences for Amelogenin Sequences. Journal of Dental Research. 2009; 88(9): 823-828.
Khanna H, Davis EE, Murga-Zamalloa CA, Estrada-Cuzcano A, Lopez I, den Hollander AI, Zonneveld MN, Othman MI, Waseem N, Chakarova CF, Maubaret C, Diaz-Font A, MacDonald I, Muzny DM, Wheeler DA, Morgan M, Lewis LR, Logan CV, Tan PL, Beer MA, Inglehearn CF, Lewis RA, Jacobson SG, Bergmann C, Beales PL, Attié-Bitach T, Johnson CA, Otto EA, Bhattacharya SS, Hildebrandt F, Gibbs RA, Koenekoop RK, Swaroop A & Katsanis N. A Common Allele in RPGRIP1L is a Modifier of Retinal Degeneration in Ciliopathies. Nature Genetics. 2009; 41:739-745.
Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O'Rourke K, Dixit VM, and Wilson AC. Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1. Molecular and Cellular Biology. 2009; 29(8):2181-2192.
Guelman S, Kozuka K, Mao Y, Pham V, Solloway M, Wang J, Wu J, Lill JR, and Zha J. The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development. Molecular and Cellular Biology. 2009; 29(5):1176-1188.
Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, and Bonni A. A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons. Cell. 2009; 136(2):322-336.
Gocke C, Yu H. ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers. PLoS ONE. 2008; 3(9):e3255.
Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, and Piao X. GPR56 Regulates Pial Basement Membrane Integrity and
Cortical Lamination. The Journal of Neuroscience. 2008; 28(22):5817–5826.
Yudin AI, Tollner TL, Treece CA, Kays R, Cherr GN, Overstreet1 JW, and Bevins CL. β-Defensin 22 is a major component of the mouse sperm glycocalyx. Reproduction. 2008; 136:753-765.
Soupene E, Serikov V, and Kuypers FA. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. Journal of Lipid Research. 2008; 49:1103-1112.
Woo S, Kim D, Jun C, Kim Y, Vander Haar E, Lee S,
Hegg JW, Bandhakavi S, Griffin TJ, and Kim D. PRR5, A Novel Component of mTOR Complex 2, Regulates PDGFRβ Expression and Signaling. Journal of Biological Chemistry. 2007; 282(35): 25604-25612.
Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung M, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, and Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metabolism. 2023; 35: 1-17. doi: 10.1016/j.cmet.2023.05.009.
Santo-Domingo J, Lassueur S, Galindo AN, Alvarez-Illera P, Romero-Sanz S, Caldero-Escudero E, de la Fuente S, Dayon L, and Wiederkehr A. SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells. Journal of Cell Science. 2023; 136(8): jcs260049. doi: 10.1242/jcs.260049.
Marr L, Biswas D, Daly LA, Browning C, Vial SCM, Maskell DP, Hudson C, Bertrand JA, Pollard J, Ranson NA, Khatter H, Eyers CE, Sakamoto K, and Zeqiraj E. Mechanism of glycogen synthase inactivation and interaction with glycogenin. Nature Communications. 2022; 13, 3372. doi: 10.1038/s41467-022-31109-6
Gyenis L, Menyhart D, Cruise ES, Jurcic K, Roffey SE, Chai DB, Trifoi F, Fess SR, Desormeaux PJ, Núñez de Villavicencio Díaz T, Rabalski AJ, Zukowski SA, Turowec JP, Pittock P, Lajoie G, and Litchfield DW. Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics. Frontiers in Molecular Biosciences. 2022; doi: 10.3389/fmolb.2022.90971.
Jeong E, Martina JA, Contreras PS, Lee J, and Puertollano R. The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. Autophagy. 2022; doi: 10.1080/15548627.2022.2029671.
Song X, Yang F, Liu X, Xia P, Yin W, Wang Z, Wang Y, Yuan X, Dou Z, Jiang K, Ma M, Hu B, Zhang R, Xu C, Zhang Z, Ruan K, Tian R, Li L, Liu T, Hill DL, Zang J, Liu X, Li J, Cheng J, and Yao X. Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nature Chemical Biology. 2021; doi: 10.1038/s41589-021-00875-7.
Wang C, Okita Y, Zheng L, Shinkai Y, Manevich L, Chin JM, Kimura T, Suzuki H, Kumagai Y,and Kato M. Glycoprotein non–metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation. Cancer Science. 2021; 112(10): 4187-4197. doi: 10.1111/cas.15090.
Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Galindo AN, Sanchez-Garcia J, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C. Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Reports. 2021; 36(8): 109565. doi: 10.1016/j.celrep.2021.109565.
Kakadia J, Biggar K, Jain B, Chen AW, Nygard K, Li C, Nathanielsz PW, Jansson T, and Gupta MB. Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture. The FASEB Journal. 2021; 35(9): e21788. doi: 10.1096/fj.202100397R.
Chiang DY, Lahiri S, Wang G, Karch J, Wang MC, Jung SY, Heck AJR, Scholten A, and Wehrens XHT. Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart. Proteomes. 2021; 9(2); 27. doi: 10.3390/proteomes9020027.
Simoneschi D, Rona G, Zhou N, Jeong Y, Jiang S, Milletti G, Arbini AA, O’Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyö D, Jones DR, Busino S, and Pagano M. CRL4AMBRA1 is a master regulator of D-type cyclins. Nature. 2021; 592: 789-793. doi: 10.1038/s41586-021-03445-y.
Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, and Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chemical Biology. 2021; doi: 10.1016/j.chembiol.2020.12.013.
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov Sd, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung M, Han L, Darabi R, Lin C, and Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nature Cell Biology. 2020; 22: 1332-1345. doi: 10.1038/s41556-020-00595-5.
Wu L, Crawley CD, Garofalo A, Nichols JW, Campbell PA, Khramtsova GF, Olopade OI, Weichselbaum RR, and Yamini B. p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability. Nature Communications. 2020; 11: 5007. doi: 10.1038/s41467-020-18838-2.
Biggar KK, Charih F, Liu H, Ruiz-Blanco YB, Stalker L, Chopra A, Connolly J, Adhikary H, Frensemier K, Hoekstra M, Galka M, Fang Q, Wynder C. Stanford WL, Green JR, and Li SSC. Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome. Cell Reports. 2020; doi: 10.1016/j.celrep.2020.107896.
Dohmen M, Krieg S, Agalaridis G, Zhu X, Shehata SN, Pfeiffenberger E, Amelang J, Bütepage M, Buerova E, Pfaff CM, Chanda D, Geley S, Preisinger C, Sakamoto K, Lüscher B, Neumann D, and Vervoorts J. AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy. Nature Communications. 2020; 11: 1032. doi: 10.1038/s41467-020-14812-0.
Yu R, Wu H, Ismail H, Du S, Cao J, Wang J, Ward T, Yang F, Gui P, Ali M, Chu L, Mo F, Wang Q, Chu Y, Zang J, Zhao Y, Ye M, Fang G, Chen PR, Dou Z, Gao X, Wang W, Liu X, and Yao X. Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics. Journal of Molecular Cell Biology. 2019; 2(6): 462-476. doi: 10.1093/jmcb/mjz107.
Ducommun S, Deak M, Zeigerer A, Göransson O, Seitz S, Collodet C, Madsen AB, Jensen TE, Viollet B, Foretz M, Gut P, Sumpton D, and Sakamoto K. Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates. Cellular Signalling. 2019; doi: 10.1016/j.cellsig.2019.02.001.
Hamilton S, Polina I, Terentyeva R, Bronk P, Kim TY, Roder K, Clements RT, Koren G, Choi B, and Terentyev D. PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.The Journal of Physiology. 2019; doi.org/10.1113/JP277618.
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung M, Danesh FR, Yang L,and Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. The Journal of Clinical Investigation. 2019; doi: 10.1172/JCI121987.
Brady OA, Jeong E, Martina J, Pirooznia M, Tunc I, and Puertollano R. The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage. eLIFE. 2019; 7:e40856. doi: 10.7554/eLife.40856.
Moruno-Manchon JF, Uzor N, Ambati CR, Shetty V, Putluri N, Jagannath C, McCullough LD, and Tsvetkov AS. Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes. Nature. 2018; doi: 10.1038/s41419-018-0599-5.
Zheng Q, Zhao Y, Guo J, Zhao S, Fei C, Xiao C, Wu D, Wu L, Li X, and Chang C. Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway. Nature. 2018; doi: 10.1038/s41419-018-0552-7.
Singal SS, Nygard K, Gratton R, Jansson T, and Gupta MB. Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. Sage Journals. 2018; 66(9): 617-630. doi: 10.1369/0022155418772574.
Kalogeropulou AF, Zhao J, Bolliger MF, Memou A, Narasimha S, Molitor TP, Wilson WH, Rideout HJ, Nichols RJ. p62/SQSTM1 is a novel Leucine Rich Repeat Kinase 2(LRRK2) substrate that enhances neuronal toxicity. Biochemical Journal. 2018; doi: 10.1042/BCJ20170699.
Frattini V, Pagnotta SM, Tala, Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Castano AM, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, and Iavarone A. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018; doi: 10.1038/nature25171.
Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R, Yao X, Wu J, and Shi Y. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. Journal of Molecular Cell Biology. 2017; doi: 10.1093/jmcb/mjx045.
Kumar S, Kim Y-R, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, and Irani K. Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. PNAS. 2017; 114(7): 1714-1719. doi: 10.1073/pnas.1614112114.
Zhang Z, Newton K, Kummerfeld SK, Webster J, Kirkpatrick DS, Phu L, Eastham-Anderson J, Liu J, Lee WP, Wu J, Li H, Junttila MR, and Dixit VM. Transcription factor Etv5 is essential for the maintenance of alveolar type II cells. PNAS. 2017; doi: 10.1073/pnas.1621177114.
Moruno-Manchon JF, Uzor N, Blasco-Conesa MP, Mannuru S, Putluri N, Furr-Stimming EE, and Tsvetkov AS. Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. Human Molecular Genetics. 2017; 26(7): 1305-1317. doi: 10.1093/hmg/ddx046.
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O’Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, and Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nature Communications 2016; doi: 10.1038/ncomms13176.
Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, dos Remedios C, He A, Bezzerides VJ, and Pu WT. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Developmental Cell. 2016; 39(4): 466-479. doi: 10.1016/j.devcel.2016.09.005.
Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, and Laird-Offringa IA. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. Journal of Neuroimmunology. 2016; 299: 70-78. doi: 10.1016/j.jneuroim.2016.09.002
Shatz W, Hass P, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DPS, Maia M, Crowell S, Dickmann L, Scheer J, and Kelley RF. Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed Through Rabbit Studies Using a Species-Matched Fab. Molecular Pharmaceutics. 2016; doi: 10.1021/acs.molpharmaceut.6b00345.
Lee SB, Frattini V, Bansal M, Castano AM, Sherman D, Hutchinson K, Bruce JN, Califano A, Liu G, Cardozo T, Iavarone A, and Lasorella A. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016; 529: 172-177; doi: 10.1038/nature16475 .
Mo F, Zhuang X, Liu X, Yao PY, Qin B, Su Z, Zang J, Wang Z, Zhang J, Dou Z, Tian C, Teng M, Niu L, Hill DL, Fang G, Ding X, Fu C, and Yao X. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature Chemical Biology. 2016; doi: 10.1038/nchembio.2017.
Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung M, Lin C, and Yang L. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nature Cell Biology. 2016; 18: 213-224; doi: 10.1038/ncb3295.
Sunkel B, Wu D, Chen Z, Wang C, Liu X, Ye Z, Horning AM, Liu J, Mahalingam D, Lopez-Nicora H, Lin C, Goodfellow PJ, Clinton SK, Jin VX, Chen C, Huang TH, and Wang Q. Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic Acids Research. 2016; doi: 10.1093/nar/gkv1528.
Shehata SN, Deak M, Morrice NA, Ohta E, Hunter RW, Kalscheuer VM, and Sakamoto K. Cyclin Y Phosphorylation- and 14-3-3-binding-dependent Activation of PCTAIRE-1/CDK16. Biochemical Journal. 2015; doi: 10.1042/BJ20150486.
Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LYJ, Win MKL, Yau YH, Guo T, See PCE, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, and Su I. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nature Immunology. 2015; (Supp)16: 505-516. doi: 10.1038/ni.3125.
Perlini LE, Szczurkowska J, Ballif BA, Piccini A, Sacchetti S, Giovedì S, Benfenati F, Cancedda L. Synapsin III Acts Downstream of Semaphorin 3A/CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons In Vivo. Cell Reports. 2015; 11: 1-15. doi: 10.1016/j.celrep.2015.03.022.
Ducommun S, Deak M, Sumpton D, Ford RJ, Galindo AN, Kussmann M, Viollet B, Steinberg GR, Foretz M, Dayon L, Morrice NA, Sakamoto K. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate. Cellular Signaling. 2015; doi: 10.1016/j.cellsig.2015.02.008.
Crawley CD, Kang S, Bernal GM, Wahlstrom JS, Voce DJ, Cahill KE, Garofalo A, Raleigh DR, Weichselbaumb RR, and Yamini B. S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability. Cell Cycle. 2015; 14(4): 566-576. doi: 10.4161/15384101.2014.991166.
Pagan JK, Marzio A, Jones MKJ, Saraf A, Jallepalli PV, Florens L, Washburn MP, and Pagano M. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology. 2015; 17: 31-43. doi: 10.1038/ncb3076.
Ultanir SK, Yadav M, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development. Neuron. 2014; doi: 10.1016/j.neuron.2014.10.025.
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, and Sakamoto K. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature. 2014; doi: 10.1038/ncomms5535.
Mazur PK, Reynoird N, Khatri P, Jansen PWTC, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, and Gozani O. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014; doi:10.1038/nature13320.
North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, and Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. 2014; doi: 10.15252/embj.201386907.
Cooper LL, Li W, Lu Y, Centraccio J, Terentyeva R, Koren G, and Terentyev D. Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts. The Journal of Physiology. 2013; doi: 10.1113/jphysiol.2013.260521.
Scholten A, Preisinger C, Corradini E, Bourgonje VJ, Hennrich ML, van Veen TAB, Swaminathan PD, Joiner M, Vos MA, Anderson ME, and Heck AJR. Phosphoproteomics Study Based on In Vivo Inhibition Reveals Sites of Calmodulin‐Dependent Protein Kinase II Regulation in the Heart.Journal of the American Heart Association. 2013; doi: 10.1161/JAHA.113.000318.
Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner MA, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, and Grumbach IM. Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Hypertension. 2013; (Suppl) 62(2):434-41. doi: 10.1161/HYPERTENSIONAHA.113.01508.
Belevych AE, Ho H, Terentyeva R, Bonilla IM, Terentyev D, Carnes CA, Gyorke S, Billman GE. Dietary Omega-3 Fatty Acids Promote Arrhythmogenic Remodeling of Cellular Ca2+ Handling in a Postinfarction Model of Sudden Cardiac Death. PLoS ONE. 2013; 8(10): e78414. doi:10.1371/journal.pone.0078414.
Jin F, Irshad S, Yu W, Belakavadi M, Chekmareva M, Ittmann MM, Abate-Shen C, and Fondell JD. ERK and AKT Signaling Drive MED1 Overexpression in Prostate Cancer in Association with Elevated Proliferation and Tumorigenicity.Molecular Cancer Research. 2013; doi: 10.1158/1541-7786.MCR-12-0618
Wu SY, Lee AY, Lai HT, Zhang H, Chiang CM. Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting. Molecular Cell. 2013; 49(5):843-857.
Shehab MA, Iosef C, Wildgruber R, Sardana G, and Gupta MB. Phosphorylation of IGFBP-1 at Discrete Sites Elicits Variable Effects on IGF-I Receptor Autophosphorylation. Endocrinology. 2013; doi: 10.1210/en.2012-1962
Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JB, Kirkpatrick DS, and Zhu H. Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations. Science Translational Medicine. 2012; DOI: 10.1126/scitranslmed.3004485.
Hermanson SB, Carlson CB, Riddle SM, Zhao J, Vogel KW, Nichols RJ, and Bi K. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation. PLoS ONE. 2012; 7(8):e43580.doi:10.1371/journal.pone.0043580.
Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos A, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, and Kruger RG. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics. 2012; 7(4): 340–343. doi: 10.4161/epi.19506.
Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, and Weissman AM. Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Molecular Cell. 2012; 47(4): 547-557. doi: 10.1016/j.molcel.2012.05.041
Urano D, Phan N, Jones JC, Yang J, Huang J, Grigston J, Taylor JP, and Jones AM. Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis. Nature Cell Biology. 2012; doi:10.1038/ncb2568.
Kang M, Chung J, and Ryoo HD. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nature Cell Biology. 2012; 14: 409-415.
Doggett, EA, Zhao, J, Mork, CN, Hu, D, and Nichols, RJ. Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition. Journal of Neurochemistry. 2012; 120(1):37–45.
Harleton E, Besana A, Comas GM, Danilo Jr P, Rosen TS, Argenziano M, Rosen MR, Robinson RB, and Feinmark SJ. Ability to Induce Atrial Fibrillation in the Peri-operative Period Is Associated with Phosphorylation-dependent Inhibition of TWIK Protein-related Acid-sensitive Potassium Channel 1 (TASK-1). The Journal of Biological Chemistry. 2012; 288: 2829-2838.
Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJP, Rustgi AK, and Diehl JA. The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation. Molecular and Cellular Biology 2011; doi:10.1128/MCB.05733-11
Gyenis L, Duncan JC, Turowec JP, Bretner M, and Litchfield DW. Unbiased Functional Proteomics Strategy for Protein Kinase Inhibitor Validation and Identification of Bona Fide Protein Kinase Substrates: Application to Identification of EEF1D as a Substrate for CK2. Journal of Proteome Research 2011; doi: 10.1021/pr2008994.
Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, and Sinclair DA. Regulation of the mPTP by SIRT3-mediated Deacetylation of CypD at Lysine 166 Suppresses Age-related Cardiac Hypertrophy. Aging. 2010; 2:12 914-923.
Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, and Diehl JA. Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase. Cancer Cell 2010; 18:4 329-340.
Kyriss MNM, Jin Y, Gallegos IJ, Sanford JA, and Wyrick JJ. Novel functional residues in the core domain of histone H2B regulate yeast gene expression and silencing and affect the response to DNA damage. Mol. Cell. Biol. 2010; 30(14) 3503-3518.
Liu Q, Busby JC, Molkentin JD. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin Defines a Signalling Nodal Control Point. Nature Cell Biology. 2009; 11(2):154-161.
MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri A, Molkentin JD and Houser SR. CaMKII Negatively Regulates Calcineurin NFAT Signaling in Cardiac Myocytes. Circulation Research. 2009; 105:316-325.
Lin D, Aggrawal P, Diehl JA. Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2–7 complex. PNAS. 2008; 105(23):8079-8084.
Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi A, Diehl JA. Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute
to Cyclin D1 Overexpression in Human Cancer. Cancer Cell. 2008; 14(1):68-78.